Most likely with annoyance.
Hachiko is that dog who waited for his owner to return for a decade or so, after he passed away, right?

What the fuzz is with her big eyes?

Big Eyes > talking anthropomorphic wolf with horns?

Wyverns - yeah ;O;

Human - big eyes were taking the piss of big puppy dog eyes, didnt really come across well @A@

I disagree, i think it came across very well. Can I suggest a link with a reference to this Hachiko thing?

It came across well :3

it looked like the character was sneezing until i clicked the wikipedia link

There is another one called "Xiao Q" quite touching... I reccomend it.